Saturday, October 5, 2019

Red Wine and Its Health Benefits for Moderate Drinkers*

Drinking red wine does not necessarily make a person alcoholic. There are people who occasionally drink it, and there are also those who regularly take it for one reason or another.

Several studies have indicated that moderate consumption of red wine can be good to human health. The list of benefits includes:
  • Nurturing cardiovascular health and liver health
  • Fighting atherosclerosis and brain diseases
  • Protecting men and women from cancer
  • Controlling inflammation and preventing acne
  • Hampering the aging process
  • Inhibiting hypertension and stroke
  • Supporting weight management
  • Reducing bad cholesterol and clotting
  • Curbing diabetes
  • Promoting good eyesight
  • Hindering osteoporosis
  • Blocking vascular injury in light smokers
  • Inducing good sleep
Other research findings have noted the following positive effects of red wine when drank moderately:




Many scientific reports discussed the positive effects of moderately drinking red wine. Such observation was noted among the local people of France. In spite of eating food with high cholesterol and fats in their diet, the fondness for red wine by the French has resulted in decreased mortality rate due to coronary heart disease, hence, the “French paradox” (Gu, Hu, & Zhang, 2015 and Ferrieres, 2004).

Besides the French, many residents of Spain, Italy and Greece and other countries near the Mediterranean Sea tend to consume red wine with their meal. This is called the "Mediterranean Diet" which consists of fruits, vegetables, fish, legumes, nuts, and whole grains, as well as the use of plant-based oils like olive oil (Mayo Clinic, 2016 and National Health Service [NHS], 2015).

What is Red Wine?

Similar to other wines, red wine is made from wine grapes, particularly black of dark-colored ones. It is a type of alcoholic beverage. In the Handbook of Enology Volume 1 The Microbiology of Wine and Vinification (2nd ed., 2006), Ribéreau-Gayon and colleagues state that:

"Red wine is a macerated wine. The extraction of solids from grape clusters (specifically from skins, seeds and possibly stems) accompanies the alcoholic fermentation of the juice" (p. 327). Puckette (2012) describes red wine taste range as "light to dark and bone-dry to sweet" (The Basic Types of Wine - Five Main Styles of Wine section, para.2).


Types of Red Wine and Food Pairings

In his online guide to wine, Breton (2015) identifies eight kinds of red wine with corresponding appropriate foods or dishes:

·    Merlot and Barbera can go with any food and are recommended for beginners or first-time drinkers of red wine.
·    Syrah/Shiraz, Cabernet Sauvignon, and Malbec complement the savor of meat.
·    Sangiovese is suited to be sipped with Italian and Meditteranean dishes.
·    Pinot Noir meshes well with salmon, chicken, and lamb, as well as sushi and other Japanese fares.
·    Zinfandel can be paired with pizza, pasta in tomato-sauce, and grilled meat.

Other types of red wine include Cabernet Franc, Gamay, Grenache/Garnacha, Mourvèdre/Mataro, Nebbiolo, Tempranillo (Rioja), Bordeaux, Carménère and Etna Roso (Gregutt, 2015 and Teeter, 2015).

For more red wine and meal combinations, the following articles provide useful information:

There are many things to think about when pairing a dish, but in the end, you have to choose which part of the dish you want to emphasize and then match the wine to that element.

Wine pairing made simple with easy wine and food recipes and tips for red wine pairings and white wine pairings.

8 basic types of wine (both red and white), including how they taste, what they look like in glass, and alternative options that have a similar taste.


Good Health Effects of Drinking Red Wine in Moderation

For several decades, clinical trials have been conducted to determine the effects of red wine's chemical compounds on human health. These chemical compounds include polyphenols (like resveratrol), melatonin, and ellargic acids, among others.

Moderate consumption of red wine is said to offer potential health benefits. Some of these reported positive effects are the following:

Nurturing cardiovascular health and liver health

The most reported benefit of red wine is related to the heart. Vorvick (2013) stated that people who drink light to moderate alcohol may have a lower chance of developing cardiac disease than the rest of the population. It appears that red wine, compared to other alcoholic drinks, offers more benefits for the heart. Such benefit is linked with resveratrol.

Based on the findings of Mayo Clinic (2014), polyphenols protect the heart’s blood vessels. This capacity is augmented by resveratrol, which acts on blood vessels and bad cholesterol (i.e. low-density lipoprotein (LDL), as well as inhibits clotting.

In 2008, researchers from the Department of Medicine of the University of California San Diego (UCSD) examined the effect of moderate wine consumption among participants of the Third National Health and Nutrition Examination Survey (NHANES III) conducted in 1988-1994 in the United States. Out of the study sample of 7,211 nondrinkers and 945 modest wine drinkers, 14.3% of the former and 8.6% of the latter were found to be at risk for both coronary heart disease (CHD) and non-alcoholic fatty liver disease (NAFLD). Findings showed an association between modest drinking or one glass a day of wine with inhibited formation NAFLD by half, as well as with cardioprotection.

The UCSD also had a study published by the European Association for the Study of the Liver in 2012. It involved 251 lifetime non-drinkers and 331 modest drinkers. The results indicated that, compared to non-drinkers, modest drinkers with NAFLD reduced their chances of having fibrosis and inflamed liver due to fat buildup, a condition known as NASH or nonalcoholic steatohepatitis (Dunn, Sanyal, Brunt, Unalp-Arida, Donohue, McCullough, Schwimmer, 2012).

In addition, study findings published in the Journal of Hepatology in 2015 stated that wine drinkers have a lower risk of having cirrhosis compared to those who consume beer and liquor. However, the researchers advised a "drink-free day" every week to decrease the probability of developing said disease among alcoholics.

Fighting atherosclerosis and brain diseases

Red wine’s chemical compounds limit the occurrence of atherosclerosis that causes blood vessels to lose their elasticity. As Szmitko and Verma (2005) explained, resveratrol helps in the formation of nitric oxide, an important chemical that promotes blood vessel wall integrity, lessens inflammatory cells sticking to the wall, and inhibits platelet formation.

Moreover, red wine reduces the risk of depression and dementia. Nordqvist (2013) cited research studies in Spain, involving 2,683 men and 2,822 women aged from 55-80 years old over a seven-year period. The outcome suggested that moderately drinking red wine (i.e. 2-7 glasses per week) may reduce the risk of depression and dementia through the action of resveratrol, which keeps the vascular wall elastic, allowing better blood supply to the brain.

The Fisher Center for Alzheimer’s Research Foundation (n.d.) at The Rockefeller University reported several studies that found moderate drinking of red wine as beneficial to brain health. Red wine could be regarded as a memory supplement, a nutrient to ward off different forms of dementia. A research conducted at the Georgetown University Medical Center in 2016 noted how resveratrol seems to protect the brain of patients with Alzheimer's disease from further inflammation and neuron damage.

Protecting men and women from cancer

Aside from its profound effect on the heart and the brain, red wine aids in preventing certain types of cancer. Referring to the work of researchers in the United Kingdom, Nordqvist (2013) pointed out that moderate drinking of red wine can lower the bowel tumor incidence rate by half. He also talked about the outcome of a research done at Cedars-Sinai Medical Center in Los Angeles that found red wine as a factor in reducing the risk of breast cancer, for it helps lower the estrogen level and raises the testosterone level in premenopausal women.

Similarly, red wine benefits men. A study published in the Harvard Men's Health Watch revealed that men who take moderate amounts of red wine have a reduced risk of being diagnosed with prostate cancer (Nordqvist, 2013). The researchers initially focused on the amount of alcohol consumed and found no correlation to said disease. However, when they later examined various alcoholic drinks, they concluded that red wine can lower the risk of prostate cancer (Nordqvist, 2013).

Besides inhibiting tumor growth in breast and in prostate, resveratrol does the same for the tissues of other body organs, such as the skin, the liver, and the colon. It also averts the development, spread, and progression of cancer cells, as well as induces cell death or apoptosis, based on the papers of the Department of Food Science and Technology's Research Group on Quality, Safety and Bioactivity of Plant Foods (2013) in Spain and the University of Connecticut's Cardiovascular Research Center (2010) in the United States.


Besides doing regular exercises, getting enough sleep, staying hydrated, and
 embracing positive thoughts, you may boost your health by
 eating the right kinds of food and moderately drinking red wine.

Controlling inflammation and preventing acne

Resveratrol in red wine is not only helpful in preventing certain types of cancer. It also shows favorable action on the inflammatory process. As stated earlier, it shields the brain from heightened inflammation. Such anti-inflammatory property though also affects the blood and the skin of moderate drinkers.

For instance, Culzac (2014) wrote about the findings of researchers from the UCLA (University of California Los Angeles) on the impact of resveratrol on acne-causing bacteria. The study showed resveratrol's ability to hinder inflammatory markers activation protein-1 (AP-1) and nuclear factor-kappa B (NF-jB) from producing acne lesions. In addition, resveratrol inhibited keratinocyte proliferation, which contributes to follicular obstruction in acne development.

Delaying the aging process

Citing a study by the Harvard Medical School, Nordqvist (2014) wrote that the anti-aging compounds in red wine prolong the life span as seen in mice. Merz (2014) reported that “…resveratrol could help humans live longer lives, by suppressing molecules which cause inflammation as well as compounds in the blood which interfere with the production of insulin” (para. 13).

In an interview with Jordan G. Teicher of Slateaging research expert Dr. David Sinclair of Harvard Medical School describes resveratrol as "...far more interesting and powerful than" functioning as an antioxidant, for it "...turns on our body's genetic defenses against diseases and aging itself." He explained that "resveratrol activates a very special enzyme in the body called SIRT1 that protects us from diseases of aging and controls how fast we age." He revealed that there are ongoing efforts to produce "...molecules that are 1000 times more effective than resveratrol at turning on SIRT1."

In their published paper on 
Oxidative Medicine and Cellular Longevity (2015), scientists from the University of Eastern Finland and the Kuopio University Hospital pointed out the therapeutic potentials of polyphenol stilbenes in controlling the impact of oxidative stress on aging cells.

Preventing hypertension and stroke

In "Effect of Resveratrol on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials" (2015), medical experts from China observed that a high dosage or ≥ 150 milligram per day (mg/d) of resveratrol could lead to reduced systolic blood pressure (SBP). On the other hand, a low dose had no significant effect on SBP and on diastolic blood pressure (DBP). The SBP is the optimal energy used by a beating heart in sending blood throughout the human body, while the DBP pertains to the least amount of energy it expends as it relaxes (Blood Pressure Association, 2008).

Hypertension can adversely affect brain health. It is regarded as the top risk factor for stroke. A 2012 clinical trial on adult rats indicated that resveratrol could protect the brain from experiencing a second stroke. Said stilbenoid helped protect the cell layer tissue (i.e. endothelium) of the blood vessels or arteries that supply blood to the brain or the cerebrovasculature (Clark et al., 2012).

In "7 Things You can Do to Prevent a Stroke" (2015), the Harvard Women's Health Watch advises drinkers to "Make red wine your first choice, because it contains resveratrol, which is thought to protect the heart and brain" (4. Drink - in moderation section, para 3).


 Supporting weight management

Researchers from the College of Agricultural Studies of Oregon State University observed how the growth of fat cells in mice was inhibited by ellargic acids found in grapes used in making red wine. Their findings were published in The Journal of Nutritional Biochemistry (2014).

Besides ellargic acids, clinical trials at the Washington State University (WSU) indicated that resveratrol aided the conversion of white fat into beige fat (Phillips, 2015). Referred to as "browning", this process burns calories or energy that affects metabolic rate and may help curb obesity. However, the scientists clarified that:

"We are using resveratrol...as a pure compound to be consistent with the study that came out 20 years ago in the medical journal, The Lancet, showing that resveratrol in wine has beneficial effects. In reality, it’s the total polyphenolic content that is more important...We think you can increase your total intake of polyphenol compounds by directly increasing fruit consumption.” (Philips, 2015, "The whole package section", paras. 3-4)

Other Benefits of Moderate Red Wine Consumption

·       Reducing bad cholesterol and clotting

Szmitko and Verma (2005) also stated that drinking moderate amounts of alcohol could elevate good cholesterol (i.e. high density lipoprotein or HDL) by 12 percent. The additional good cholesterol could offset the amount of bad cholesterol in the blood, thereby decreasing fatty plaque formation. When this fatty plaque ruptures due to conditions like myocardial infarction or cerebrovascular disease (stroke), the plaque is exposed and acted upon by resveratrol to prevent clotting (Szmitko & Verma, 2005).

·       Curbing diabetes

In a clinical trial conducted in New York in 2012, researchers observed that resveratrol enhanced insulin sensitivity and glucose tolerance. This finding supported the result of an experiment by medical experts in Hungary in 2011 in which resveratrol "...improved insulin resistance, decreased blood glucose levels and delayed the appearance of glucose peaks after a test meal..." (Tomé-Carneiro, Larrosa, González-Sarrías, Tomás-Barberán, García-Conesa, & Espín, 2013, p. 6072).

·       Promoting good eyesight

Resveratrol is among the many essential nutrients that support a healthy vision (Parry, 2015). A research published in Cell Metabolism in 2008 indicated reduced cataracts and other positive effects of said compound in mice.

A study in 2014 further noted its role in preventing eye disorders, such as age-related macular degeneration (AMD) that results in blurry and distorted vision, as well as diminished perception of color. AMD is said to be the primary cause of vision loss among people aged 50 years old and above. Health experts at the Washington University School of Medicine and the University of Dentistry and Medicine of New Jersey observed that resveratrol helps deter the abnormal growth of blood vessels that can harm the eye due to aging (Alleyne, 2010).

·       Hindering osteoporosis

Research findings published on the Journal of Clinical Endocrinology & Metabolism in 2014 noted reveratrol's anti-osteoporosis potential. Medical experts from Denmark observed the effect of said compound on 66 middle-aged men with metabolic syndrome that contributes to bone loss. They found that resveratrol could stimulate body cells meant for bone formation, as well as improve bone mineral density.

·       Blocking vascular injury in light smokers

Citing a study done by the University of Saarland in Germany, the Institute for Natural Healing or INH (2016) reported that phenol in red wine helps keep endothelial cells in the lining of blood vessels healthy. When a person smokes, his/her bloodstream gets exposed to toxic chemicals or microparticles causing "...inflammation that prematurely ages the endothelial cells...". Drinking red wine prior to smoking spurs the production of nitric oxide that protects endothelial cells. This short-term benefit, however, is not for heavy smokers or those who puff one pack of cigarettes or more daily.

·       Inducing good sleep

Red wine has another chemical which is also found in the skins of red grapes – melatonin. Storino and Golbin (2009) claimed that melatonin enhances circadian rhythms, inducing better night sleep. They explained that:

"Essentially, melatonin makes us active during the day and sleepy in the dark of night. In our bodies, melatonin levels peak in the evenings and decrease around dawn. With an extra glass of wine at night, we enhance our body's melatonin peak, thereby ushering in a restful night". (para. 2)

What is Moderate Drinking of Red Wine?

Not everyone knows what moderate drinking means. According to Puckette (2014), a standard drink contains 5-6 ounces (~150-180ml) or about 3/4 of a regular cup.

The Mayo Clinic (n.d.) specifies that a drink pertains to any of the following:

·       12 ounces (355 milliliters, or mL) of beer
·       5 ounces (148 mL) of wine
·       1.5 ounces (44 mL) of 80-proof distilled spirits

For some doctors (like Dr. Josh Axe who is featured in this hub's video), average consumption of red wine means "a glass a couple of days a week". Dunn, Xu and Schwimmer (2008) described modesty in consuming alcohol as "up to an average of one drink per day. One drink is defined as 12 ounces of beer, 4 ounces of wine, or 1 ounce of liquor" (Patients and Methods section, para. 2).
Moderately consuming red wine means
1-2 glasses of 4-5 ounces daily or a couple of days a week.
Image Source: Skitterphoto from Pexels

On the other hand, the 2016 European clinical practice guidelines on cardiovascular disease prevention define light-to-moderate drinking of alcoholic beverage as 15–30 grams (g) per day of ethanol, which is around 130–250 mL of wine/day (Markoski, Garavaglia, Oliveira, Olivaes,& Marcadenti, 2016).

Recommendations for moderate drinking of red wine vary for men and women. Godman (2014) states: "... no more than one drink day for women, and no more than two drinks a day for men" (Drink in moderation - or not at all section, para. 8).

Red Wine – A Different View on Its Impact on Human Health

Notwithstanding red wine’s advantages, there are research findings that contradict such notions. Dr. Richard Semba and colleagues (2014) conducted a study in Italy in which 783 elderly men and women (i.e. aged 65 years old and above) participated from 1998 to 2009. They attempted to investigate if a diet-induced resveratrol level had a positive impact on inflammation, cancer, cardiovascular disease, and human longevity. They observed that said antioxidant does not have any direct effect on such conditions.

Dr. Semba posited that any benefit of red wine, if present, may come from other compounds and not only from resveratrol (Roberts, 2014). He and his fellow researchers described their work as pioneering for piloting a study that examined the effects of diet-based resveratrol to human health through urine samples (Ellis, 2013).

Furthermore, as explained by WSU Professor Min Du who examined the effects of resveratrol on excess white fat in mice, red wines only consist of minimal amounts of phenolic compounds. He pointed out that “Many of the beneficial polyphenols are insoluble and get filtered out during the wine production process.” Thus, he advised that instead of drinking red wine,it is better to eat fruits rich in resveratrol, such as blueberries, strawberries, raspberries, grapes and apples (Phillips, 2015).


In spite of the opposing views given by Dr. Semba et al., there is no clear answer if resveratrol in red wine is truly valuable or not to an individual. Roberts (2014) opined that more clinical research and experiments are necessary to establish red wine’s effects on human health.

Red Wine's Probable Health Merits - A Recap

Published clinical studies about red wine state its seeming favorable effects on moderate drinkers. Made out of fermented grapes and paired with different types of food, it is reported to reduce the risk of developing various diseases (e.g., dementia, hypertension, cancer, NFLD, cirrhosis, AMD, acne) by improving the health of the following body organs:

·       Brain
·       Heart
·       Liver
·       Eyes
·       Skin

Consuming 1-2 glasses of red wine a day may also contribute to:

·       Curbing obesity and diabetes
·       Protecting blood vessels and inhibiting atherosclerosis
·       Activating or reinforcing cells for bone formation

·       Promotes anti-aging and restful bedtime

Despite these findings, some health experts caution that such results are inconclusive, for red wine contains a small amount of beneficial chemical compounds. Thus, further medical research is needed to strongly establish its positive effects on moderate drinkers.


Other Cited References
Andres-Lacueva, C., Bandinelli, S., Bartali, B., Cherubini, A., Ferrucci, L., Semba, R.D., Sun, K., Urpi-sarda, M. & Zamora-Ros, R. (2014). Resveratrol levels and all-cause mortality in older community-dwelling adults. JAMA Internal Medicine174(7):1077-1084. doi:10.1001/jamainternmed.2014.1582

Culzac, N. (2014). Antioxidant in red wine could help reduce acne, study saysThe Independent.

Ellis, M. (2014). Health benefits of red wine antioxidant questioned in studyMedical News Today.

Ferrieres, J. (2004). The French Paradox: Lessons for other countries. Heart. 90:107-111

Mayo Clinic. (2014). Diseases and Conditions.

Merz, T. (2014). Red wine: the unexpected health benefitsTelegraph.

Nordqvist, C. (2013). What are the benefits of wineMedical News Today.

Phillips, R. (2015). WSU scientists turn white fat into obesity-fighting beige fat.

Roberts, M. (2014). Red wine health benefits “overhyped”BBC NEWS.

Szmitko, P.E. & Verma, S. (2005). Red wine and your heartCirculation. 111:e10-e11. doi:10.1161/01.CIR.0000151608.29217.62

Storino, J., Golbin, Y. (2009). Dorma, dorma, dorma...Sleep and Health Journal.

Vorvick, L. J. (2013). Wine and heart health.


Note: *A.M. Samson, a US-based registered nurse, co-wrote some parts of this article.

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